Low arterial oxygen partial pressure induces pulmonary thrombocytopenia in patients and a mouse model.

ABSTRACT:

Background

Recent basic studies demonstrate that the lung is a primary organ of platelet biogenesis. However, whether the pathophysiological state of the lung affect the platelets is little known. We aim to investigate the incidence of thrombocytopenia in patients with pulmonary infection (PIN) and risk factors associated with pulmonary thrombocytopenia.

Methods

In total, 11,941 patients with pulmonary infection (PIN) were enrolled, and patients with other three infectious diseases were collected as controls. The incidence of thrombocytopenia was compared, and the risk factors associated with thrombocytopenia in PIN patients were investigated by multivariate analysis. To explore the mechanism of thrombocytopenia, hypoxic model was constructed. Blood platelet counts from the

SUBMITTER: Wu L 

PROVIDER: S-EPMC7789170 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature