DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna.

ABSTRACT:

Background

Patterns of methylation influence lifespan, but methylation and lifespan may also depend on diet, or differ between genotypes. Prior to this study, interactions between diet and genotype have not been explored together to determine their influence on methylation. The invertebrate Daphnia magna is an excellent choice for testing the epigenetic response to the environment: parthenogenetic offspring are identical to their siblings (making for powerful genetic comparisons), they are relatively short lived and have well-characterised inter-strain life-history trait differences. We performed a survival analysis in response to caloric restriction and then undertook a 47-replicate experiment testing the DNA methylation response to ageing and caloric restriction of two strains of

SUBMITTER: Hearn J 

PROVIDER: S-EPMC7789248 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature