The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat.

ABSTRACT:

Background

Sepsis has a high mortality rate, but no specific drug has been proven effective, prompting the development of new drugs. Immunologically, sepsis can involve hyperinflammation, immune paralysis, or both, which might pose challenges during drug development. Recently, mitochondrial transplantation has emerged as a treatment modality for various diseases involving mitochondrial dysfunction, but it has never been tested for sepsis.

Methods

We isolated mitochondria from L6 muscle cells and umbilical cord mesenchymal stem cells and tested the quality of the isolated mitochondria. We conducted both in vivo and in vitro sepsis studies. We investigated the effects of intravenous mitochondrial transplantation on cecal slurry model in rats in terms of survival rate, bacteria

SUBMITTER: Hwang JW 

PROVIDER: S-EPMC7789332 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature