IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients.

ABSTRACT:

Background

Preeclampsia (PE) is a pregnancy-related condition that affects both the infant and the mother. Although the role of various inflammatory molecules in PE has been demonstrated, the importance of pro-inflammatory molecules such as IL-17A, IL-23 is not well understood. In the present investigation, a potential association of common genetic variants in the IL-17A and IL-23A genes with PE was investigated.

Methods

115 PE clinically diagnosed patients who registered to the International Peace Maternity and Child Health Hospital were enrolled in this research. One hundred two pregnant women and 147 healthy Chinese women were also included. ELISA was used to measure IL-17A and IL-23 serum levels in all enrolled subjects. Common genetic polymorphisms in IL-17A (rs 2,275,9

SUBMITTER: Lang X 

PROVIDER: S-EPMC7789345 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature