Prognostic factors of non-muscle invasive bladder cancer: a study based on next-generation sequencing.

ABSTRACT:

Objective

To investigate the genetic prognostic factors for the recurrence of non-muscle invasive bladder cancer.

Materials and methods

The patients underwent transurethral resection of bladder tumor and received bacillus Calmette-Guérin (BCG) or epirubicin. Next-generation sequencing was performed and alterations of genes, pathways, and tumor mutation burden were recorded. Associations between these clinicopathological and genetic variants were estimated, and prognostic factor identified.

Results

A total of 58 cases were included in our study, and 46 patients underwent treatment with BCG. FGFR3 was the most frequently altered gene (48%), and more commonly detected in intermediate-risk patients. Univariate Cox analysis demonstrated that 10 genes were significantly cor

SUBMITTER: Shao Y 

PROVIDER: S-EPMC7789352 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature