Clinical evaluation of neuroinflammation in child-onset focal epilepsy: a translocator protein PET study.

ABSTRACT:

Background

Neuroinflammation is associated with various chronic neurological diseases, including epilepsy; however, neuroimaging approaches for visualizing neuroinflammation have not been used in the clinical routine yet. In this study, we used the translocator protein positron emission tomography (PET) with [¹¹C] DPA713 to investigate neuroinflammation in the epileptogenic zone in patients with child-onset focal epilepsy.

Methods

Patients with intractable focal epilepsy were recruited at the Epilepsy Center of Osaka University; those who were taking any immunosuppressants or steroids were excluded. PET images were acquired for 60 min after intravenous administration of [¹¹C] DPA713. The PET image of [¹¹C] DPA713 was co-registered to individu

SUBMITTER: Kagitani-Shimono K 

PROVIDER: S-EPMC7789379 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature