Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis.

ABSTRACT:

Background

Acute kidney injury (AKI) is a common serious complication in critically ill patients. AKI occurs in up to 50% patients in intensive care unit (ICU), with poor clinical prognosis. Renal replacement therapy (RRT) has been widely used in critically ill patients with AKI. However, in patients without urgent indications such as acute pulmonary edema, severe acidosis, and severe hyperkalemia, the optimal timing of RRT initiation is still under debate. We conducted this systematic review of randomized clinical trials (RCTs) with meta-analysis and trial sequential analysis (TSA) to compare the effects of early RRT initiation versus delayed RRT initiation.

Methods

We searched databases (PubMed, EMBASE and Cochrane Library) from inception through to July 20, 2020, to ident

SUBMITTER: Li X 

PROVIDER: S-EPMC7789484 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature