Examination of hydrogen cross-feeders using a colonic microbiota model.

ABSTRACT:

Background

Hydrogen cross-feeding microbes form a functionally important subset of the human colonic microbiota. The three major hydrogenotrophic functional groups of the colon: sulphate-reducing bacteria (SRB), methanogens and reductive acetogens, have been linked to wide ranging impacts on host physiology, health and wellbeing.

Results

An existing mathematical model for microbial community growth and metabolism was combined with models for each of the three hydrogenotrophic functional groups. The model was further developed for application to the colonic environment via inclusion of responsive pH, host metabolite absorption and the inclusion of host mucins. Predictions of the model, using two existing metabolic parameter sets, were compared to experimental faecal culture d

SUBMITTER: Smith NW 

PROVIDER: S-EPMC7789523 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature