Integrated analysis of the methylome and transcriptome of chickens with fatty liver hemorrhagic syndrome.

ABSTRACT:

Background

DNA methylation, a biochemical modification of cytosine, has an important role in lipid metabolism. Fatty liver hemorrhagic syndrome (FLHS) is a serious disease and is tightly linked to lipid homeostasis. Herein, we compared the methylome and transcriptome of chickens with and without FLHS.

Results

We found genome-wide dysregulated DNA methylation pattern in which regions up- and down-stream of gene body were hypo-methylated in chickens with FLHS. A total of 4155 differentially methylated genes and 1389 differentially expressed genes were identified. Genes were focused when a negative relationship between mRNA expression and DNA methylation in promoter and gene body were detected. Based on pathway enrichment analysis, we found expression of genes related to lipoge

SUBMITTER: Tan X 

PROVIDER: S-EPMC7789526 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature