Structural disruption of the blood-brain barrier in repetitive primary blast injury.

ABSTRACT:

Background

Blast-induced traumatic brain injury (bTBI) is a growing health concern due to the increased use of low-cost improvised explosive devices in modern warfare. Mild blast exposures are common amongst military personnel; however, these women and men typically do not have adequate recovery time from their injuries due to the transient nature of behavioral symptoms. bTBI has been linked to heterogeneous neuropathology, including brain edema, neuronal degeneration and cognitive abnormalities depending on the intensity of blast overpressure and frequency. Recent studies have reported heterogeneity in blood-brain barrier (BBB) permeability following blast injury. There still remains a limited understanding of the pathologic changes in the BBB following primary blast injuries. In

SUBMITTER: Uzunalli G 

PROVIDER: S-EPMC7789532 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature