DNA methylation abnormalities of imprinted genes in congenital heart disease: a pilot study.

ABSTRACT:

Background

Congenital heart disease (CHD) is resulted from the interaction of genetic aberration and environmental factors. Imprinted genes, which are regulated by epigenetic modifications, are essential for the normal embryonic development. However, the role of imprinted genes in the etiology of CHD remains unclear.

Methods

After the samples were treated with bisulfate salt, imprinted genes methylation were measured by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. T test and One-way ANOVA were performed to evaluate the differences among groups. Odds ratios (ORs) were performed to evaluate the incidence risk of CHD in relation to methylation levels.

Results

We investigated the alterations of imprinted gene germline differential methylat

SUBMITTER: Chang S 

PROVIDER: S-EPMC7789576 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature