An integrated multi-omics approach to identify regulatory mechanisms in cancer metastatic processes.

ABSTRACT:

Background

Metastatic progress is the primary cause of death in most cancers, yet the regulatory dynamics driving the cellular changes necessary for metastasis remain poorly understood. Multi-omics approaches hold great promise for addressing this challenge; however, current analysis tools have limited capabilities to systematically integrate transcriptomic, epigenomic, and cistromic information to accurately define the regulatory networks critical for metastasis.

Results

To address this limitation, we use a purposefully generated cellular model of colon cancer invasiveness to generate multi-omics data, including expression, accessibility, and selected histone modification profiles, for increasing levels of invasiveness. We then adopt a rigorous probabilistic framework for j

SUBMITTER: Ghaffari S 

PROVIDER: S-EPMC7789593 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature