Ferulic acid attenuates microglia-mediated neuroinflammation in retinal degeneration.

ABSTRACT:

Background

Retinal degeneration is often accompanied by microglia-mediated neuroinflammation. Ferulic acid (FA), an active ingredient of traditional Chinese medicines (TCMs), has been reported to have anti-inflammatory effects. This study explores the impact of FA on microglia-mediated neuroinflammation and associated retinal degeneration in rd10 mice.

Methods

Rd10 mice received different concentrations of FA every day from postnatal day (P)4 to P24. On P25, the visual function of the mice was evaluated by electroretinogram, and retinae were collected for further investigation. Microglial activation and the expression of relevant cytokines in the retina were evaluated by qPCR, western blotting and immunofluorescence staining. Retinal structure was assessed by haematoxylin an

SUBMITTER: Sun X 

PROVIDER: S-EPMC7789661 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature