A roadmap of brain recovery in a mouse model of concussion: insights from neuroimaging.

ABSTRACT: Concussion or mild traumatic brain injury is the most common form of traumatic brain injury with potentially long-term consequences. Current objective diagnosis and treatment options are limited to clinical assessment, cognitive rest, and symptom management, which raises the real danger of concussed patients being released back into activities where subsequent and cumulative injuries may cause disproportionate damages. This study conducted a cross-sectional multi-modal examination investigation of the temporal changes in behavioural and brain changes in a mouse model of concussion using magnetic resonance imaging. Sham and concussed mice were assessed at day 2, day 7, and day 14 post-sham or injury procedures following a single concussion event for motor deficits, psychological symptoms wi

SUBMITTER: To XV 

PROVIDER: S-EPMC7789702 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature