Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea.

ABSTRACT:

Background

Obstructive Sleep Apnea (OSA) is a highly prevalent condition that is associated with several comorbidities including cardiovascular disease (CVD). Recent studies have revealed mixed results as to whether standard OSA therapy reverses CVD in adult patients. Thus, many advocate for earlier recognition of OSA induced CVD, as early as childhood, to prompt treatment antecedent to the onset of irreversible CVD. Here we investigated if the serum level of miR-92a, a known biomarker for CVD, can be used to identify patients with OSA in both children and adults.

Methods

Consecutive snoring patients undergoing polysomnography were recruited for determination of circulating miR-92a, in addition to inflammatory and metabolic profiles. We assessed whether circulating miR-92a w

SUBMITTER: Gongol B 

PROVIDER: S-EPMC7789821 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature