Use of proton pump inhibitors to treat persistent throat symptoms: multicentre, double blind, randomised, placebo controlled trial.

ABSTRACT:

Objective

To assess the use of proton pump inhibitors (PPIs) to treat persistent throat symptoms.

Design

Pragmatic, double blind, placebo controlled, randomised trial.

Setting

Eight ear, nose, and throat outpatient clinics, United Kingdom.

Participants

346 patients aged 18 years or older with persistent throat symptoms who were randomised according to recruiting centre and baseline severity of symptoms (mild or severe): 172 to lansoprazole and 174 to placebo.

Intervention

Random blinded allocation (1:1) to either 30 mg lansoprazole twice daily or matched placebo twice daily for 16 weeks.

Main outcome measures

Primary outcome was symptomatic response at 16 weeks measured using the total reflux symptom index (RSI) score. Secondary outcomes included

SUBMITTER: O'Hara J 

PROVIDER: S-EPMC7789994 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature