Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of K_ATP, BK_Ca and L-type Ca²⁺ channels.

ABSTRACT: Formaldehyde (FA), a well-known toxic gas molecule similar to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H₂S), is widely produced endogenously via numerous biochemical pathways, and has a number of physiological roles in the biosystem. We attempted to investigate the vasorelaxant effects of FA and their underlying mechanisms. We found that FA induced vasorelaxant effects on rat aortic rings in a concentration-dependent manner. The NO/cyclic guanosine 5' monophosphate (cGMP) pathway was up-regulated when the rat aortas were treated with FA. The expression of large-conductance Ca²⁺-activated K⁺ (BK_Ca) channel subunits α and β of the rat aortas was increased by FA. Similarly, the levels of ATP-sensitive K⁺ (K_ATP</

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7790163 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature