Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy.

ABSTRACT:

Background

Eighteen known susceptibility loci for IgAN account for only a small proportion of IgAN risk.

Methods

Genome-wide meta-analysis was performed in 2628 patients and 11,563 controls of Chinese ancestry, and a replication analysis was conducted in 6879 patients and 9019 controls of Chinese descent and 1039 patients and 1289 controls of European ancestry. The data were used to assess the association of susceptibility loci with clinical phenotypes for IgAN, and to investigate genetic heterogeneity of IgAN susceptibility between the two populations. Imputation-based analysis of the MHC/HLA region extended the scrutiny.

Results

Identification of three novel loci (rs6427389 on 1q23.1 [P=8.18×10^-9, OR=1.132], rs6942325 on 6p25.3 [P=1.62×10

SUBMITTER: Li M 

PROVIDER: S-EPMC7790208 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature