The genetic proteome: Using genetics to inform the proteome of mycobacterial pathogens.

ABSTRACT: Mycobacterial pathogens pose a sustained threat to human health. There is a critical need for new diagnostics, therapeutics, and vaccines targeting both tuberculous and nontuberculous mycobacterial species. Understanding the basic mechanisms used by diverse mycobacterial species to cause disease will facilitate efforts to design new approaches toward detection, treatment, and prevention of mycobacterial disease. Molecular, genetic, and biochemical approaches have been widely employed to define fundamental aspects of mycobacterial physiology and virulence. The recent expansion of genetic tools in mycobacteria has further increased the accessibility of forward genetic approaches. Proteomics has also emerged as a powerful approach to further our understanding of diverse mycobacterial species.

SUBMITTER: Nicholson KR 

PROVIDER: S-EPMC7790235 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature