A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients.

ABSTRACT:

Purpose

COVID-19 pandemic has multifaceted presentations with rising evidence of immune-mediated mechanisms underplay. We sought to explore the outcomes of severe COVID-19 patients treated with a multi-mechanism approach (MMA) in addition to standard-of-care (SC) versus patients who only received SC treatment.

Materials and methods

Data were collected retrospectively for patients admitted to the intensive care unit (ICU). This observational cohort study was performed at five institutions, 3 in the United States and 2 in Honduras. Patients were stratified for MMA vs. SC treatment during ICU stay. MMA treatment consists of widely available medications started immediately upon hospitalization. These interventions target immunomodulation, anticoagulation, viral suppression, and

SUBMITTER: Valerio Pascua F 

PROVIDER: S-EPMC7790264 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature