Altered acylated ghrelin response to food intake in congenital generalized lipodystrophy.

ABSTRACT:

Background

Patients with congenital generalized lipodystrophy (CGL) have very low levels of leptin and are described as having a voracious appetite. However, a direct comparison between CGL and eutrophic individuals is lacking, regarding both appetite parameters and acylated ghrelin, the hormone form that is active in acute food intake stimulation. The objective of the present study was to address whether and in what extent the subjective appetite parameters and acylated ghrelin response to a meal are affected in CGL individuals, in comparison to eutrophic individuals. Additionally, an obese group was included in the study, to allow the comparison between a leptin-resistant and a leptin-deficient condition on these aspects.

Methods

Eutrophic controls (EUT, n = 10), obese sub

SUBMITTER: Araujo COD 

PROVIDER: S-EPMC7790291 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature