Women design their own vaginal microbicide trial: Suggestions on how to improve adherence from former participants of HIV prevention trials.

ABSTRACT: Low adherence in vaginal microbicide clinical trials for HIV prevention has impeded interpretation of trial results and hindered evaluation of potentially efficacious HIV prevention gels. Understanding the underlying reasons why women join trials and their barriers to product use can support identification of ways to improve adherence and its reporting. Eight focus group discussion workshops were conducted with 46 former microbicide trial participants in Durban, South Africa and Mwanza, Tanzania. Participants provided feedback on why women join trials, the barriers to using study gel and reporting adherence accurately, and how clinical trial design can be improved to support better adherence and its reporting. Women join microbicide trials for a number of important reasons such as healthca

SUBMITTER: Miller L 

PROVIDER: S-EPMC7790400 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature