Multi-scale modeling of macrophage-T cell interactions within the tumor microenvironment.

ABSTRACT: Within the tumor microenvironment, macrophages exist in an immunosuppressive state, preventing T cells from eliminating the tumor. Due to this, research is focusing on immunotherapies that specifically target macrophages in order to reduce their immunosuppressive capabilities and promote T cell function. In this study, we develop an agent-based model consisting of the interactions between macrophages, T cells, and tumor cells to determine how the immune response changes due to three macrophage-based immunotherapeutic strategies: macrophage depletion, recruitment inhibition, and macrophage reeducation. We find that reeducation, which converts the macrophages into an immune-promoting phenotype, is the most effective strategy and that the macrophage recruitment rate and tumor proliferation ra

SUBMITTER: Cess CG 

PROVIDER: S-EPMC7790427 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature