Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder.

ABSTRACT:

Objectives

Emotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suicide risk factor. We assessed brain responses during explicit emotion regulation, and their relationship with hopelessness, in acutely symptomatic and euthymic individuals with BD.

Methods

Functional MRI data were obtained from individuals with BD who were either in acute negative (BD-A; n = 24) or euthymic (BD-E; n = 24) mood states, and from healthy volunteers (HV; n = 55), while participants performed a paradigm that instructed them to downregulate their respo

SUBMITTER: Sankar A 

PROVIDER: S-EPMC7790437 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature