MicroCT vascular network analysis program: Development, validation, and comparison to manufacturer software.

ABSTRACT: The dependence on angiogenesis for bone repair makes accurate measuring of vascular networks of great importance to orthopedic researchers. A three-dimensional imaging modality like microcomputed tomography (µCT) would better capture these networks than histology. There are commercially available programs to analyze vessel networks in three dimensions, but these may be too costly for laboratories. Alternatively, µCT trabecular software could be used but may not be appropriate. The goal of this project was to develop a vascular network analysis protocol based on freely or commonly available software and compare its performance to that of a µCT trabecular analysis software. The protocol developed, called vascular network analysis or VNA, relies on two modules in Fiji ImageJ and a custom MATL

SUBMITTER: Peters J 

PROVIDER: S-EPMC7790441 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature