Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses.

ABSTRACT: Synthesis of extracellular adenosine by the ectonucleotidases CD39 and CD73 represents an important pathway of immune suppression in the tumor microenvironment. Using two mouse models (RET transgenic melanoma and Panc02 orthotopic pancreatic adenocarcinoma), we identified an elevated frequency of ectonucleotidase-expressing T cells in tumors and spleens. Importantly, these ectonucleotidase-positive T cells also showed a pronounced expression of PD-1. Conversely, the PD-1⁺ T cell subsets in tumors contained substantially larger proportions of ectonucleotidase-expressing cells compared to their counterparts lacking PD-1 expression. Our in vitro experiments showed that the activation of normal T cells resulted in an increase in the CD39 expression. CD39⁺ an

SUBMITTER: Shevchenko I 

PROVIDER: S-EPMC7790505 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature