Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis.

ABSTRACT:

Background

Interleukin-18 (IL-18) and interferon-γ (IFN-γ) are cytokines of crucial role in inflammation and immune reactions. There is a growing evidence supporting important roles for IL-18 and IFN γ in tuberculosis (TB) infection and anti-tuberculosis immunity.

Objective

To evaluate the role of polymorphisms in IL-18-607 and -137 and INF-γ +874 in susceptibility to TB infection among Egyptian patients.

Methods

A case control study was conducted to investigate the polymorphism at IL-18-607, -137 and INF-γ+874 by sequence specific primer-polymerase chain reaction (SSP- PCR) in 105 patients with pulmonary and extra pulmonary tuberculosis and 106 controls.

Results

A significant protective effect against TB was found in homozygous CC genotype at IL-18 -137G/C, in

SUBMITTER: Hassuna NA 

PROVIDER: S-EPMC7790531 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature