Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: Insights from an agent-based model.

ABSTRACT: Intestinal crypts are responsible for the total cell renewal of the lining of the intestines; this turnover is governed by the interplay between signalling pathways and the cell cycle. The role of Wnt signalling in cell proliferation and differentiation in the intestinal crypt has been extensively studied, with increased signalling found towards the lower regions of the crypt. Recent studies have shown that the Wnt signalling gradient found within the crypt may arise as a result of division-based spreading from a Wnt 'reservoir' at the crypt base. The discovery of the Hippo pathway's involvement in maintaining crypt homeostasis is more recent; a mechanistic understanding of Hippo pathway dynamics, and its possible cross-talk with the Wnt pathway, remains lacking. To explore how the interpl

SUBMITTER: Ward D 

PROVIDER: S-EPMC7790739 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature