Glucose metabolism characteristics and TLR8-mediated metabolic control of CD4⁺ Treg cells in ovarian cancer cells microenvironment.

ABSTRACT: Immunotherapy is expected to become the most promising new treatment for ovarian cancer owing to its immunogenicity. However, immunosuppression in the tumor microenvironment is a major obstacle to the efficacy of tumor therapy. Studies have found different metabolism ways of regulatory T cells (Tregs) in the cancer environment may be related to the immunosuppression and Toll-like receptor 8 (TLR8) can reverse the suppression function of Tregs. But it is still unclear that if the TLR8-mediated function reversal is associated with the change of glucose metabolism of Tregs. It was found that the positive expression rates of Glut1, HIF-1α, and Ki67 in CD4⁺ Treg cells of OC were significantly higher than that in benign ovarian tumor and HC, and also significantly higher than that in

SUBMITTER: Xu R 

PROVIDER: S-EPMC7790820 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature