Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca²⁺ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca²⁺ Dynamics.

ABSTRACT:

Rationale

Ca²⁺-induced Ca²⁺ release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum. CICR is disrupted in cardiac hypertrophy and heart failure, which is associated with loss of T-tubules and disruption of cardiac dyads. In these conditions, LTCCs are redistributed from the T-tubules to disrupt CICR. The molecular mechanism responsible for LTCCs recruitment to and from the T-tubules is not well known. JPH (junctophilin) 2 enables close association between T-tubules and the junctional sarcoplasmic reticulum to ensure efficient CICR. JPH2 has a so-called joining region that is located near domains that inter

SUBMITTER: Gross P 

PROVIDER: S-EPMC7790862 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature