Consistency and variation of protein subcellular location annotations.

ABSTRACT: A major challenge for protein databases is reconciling information from diverse sources. This is especially difficult when some information consists of secondary, human-interpreted rather than primary data. For example, the Swiss-Prot database contains curated annotations of subcellular location that are based on predictions from protein sequence, statements in scientific articles, and published experimental evidence. The Human Protein Atlas (HPA) consists of millions of high-resolution microscopic images that show protein spatial distribution on a cellular and subcellular level. These images are manually annotated with protein subcellular locations by trained experts. The image annotations in HPA can capture the variation of subcellular location across different cell lines, tissues, or ti

SUBMITTER: Xu YY 

PROVIDER: S-EPMC7790864 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature