Long-term outcomes of anterior cruciate ligament reconstruction surgery: 2020 OREF clinical research award paper.

ABSTRACT: ACL injuries place the knee at risk for post-traumatic osteoarthritis (PTOA) despite surgical anterior cruciate ligament (ACL) reconstruction. One parameter thought to affect PTOA risk is the initial graft tension. This randomized controlled trial (RCT) was designed to compare outcomes between two graft tensioning protocols that bracket the range commonly used. At 7 years postsurgery, we determined that most outcomes between the two tension groups were not significantly different, that they were inferior to an uninjured matched control group, and that PTOA was progressing in both groups relative to controls. The trial database was also leveraged to gain insight into mechanisms of PTOA following ACL injury. We determined that the inflammatory response at the time of injury undermines one of

SUBMITTER: Fleming BC 

PROVIDER: S-EPMC7790866 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature