A two-step gas chromatography-tandem mass spectrometry method for measurement of multiple environmental pollutants in human plasma.

ABSTRACT: Individuals are exposed to a wide variety of chemicals over their lifetime, yet current understanding of mixture toxicology is still limited. We present a two-step analytical method using a gas chromatograph-triple quadrupole mass spectrometer that requires less than 1 mL of sample. The method is applied to 183 plasma samples from a study population of children with autism spectrum disorder, their parents, and unrelated neurotypical children. We selected 156 environmental chemical compounds and ruled out chemicals with detection rates less than 20% of our study cohort (n = 61), as well as ones not amenable to the selected extraction and analytical methods (n = 34). The targeted method then focused on remaining chemicals (n = 61) plus 8 additional polychlorinated biphenyls (PCBs). Persisten

SUBMITTER: Johnson CL 

PROVIDER: S-EPMC7790997 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature