CTRP13 Mitigates Abdominal Aortic Aneurysm Formation via NAMPT1.

ABSTRACT: Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease characterized by localized dilation of the abdominal aorta. C1q/tumor necrosis factor (TNF)-related protein-13 (CTRP13) is a secreted adipokine that plays important roles in the cardiovascular system. However, the functional role of CTRP13 in the formation and development of AAA has yet to be explored. In this study, we determined that serum CTRP13 levels were significantly downregulated in blood samples from patients with AAA and in rodent AAA models induced by Angiotensin II (Ang II) in ApoE^-/- mice or by CaCl₂ in C57BL/6J mice. Using two distinct murine models of AAA, CTRP13 was shown to effectively reduce the incidence and severity of AAA in conjunction with reduced aortic macrophage infi

SUBMITTER: Xu W 

PROVIDER: S-EPMC7791009 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature