ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway.

ABSTRACT: Hepatocellular carcinoma (HCC) has been extensively studied as one of the most aggressive tumors worldwide. However, its mortality rate remains high due to ideal diagnosis and treatment strategies. Uncovering novel genes with prognostic significance would shed light on improving the HCC patient's outcome. In our study, we applied data-independent acquisition (DIA) quantitative proteomics to investigate the expression landscape of 24 paired HCC patients. A total of 1029 differentially expressed proteins (DEPs) were screened. Then, we compared DEPs in our cohort with the differentially expressed genes (DEGs) in The Cancer Genome Atlas, and investigated their prognostic significance, and found 183 prognosis-related genes (PRGs). By conducting protein-protein interaction topological analysis,

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7791021 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature