Liver fibrosis-induced muscle atrophy is mediated by elevated levels of circulating TNFα.

ABSTRACT: Liver cirrhosis is a critical health problem associated with several complications, including skeletal muscle atrophy, which adversely affects the clinical outcome of patients independent of their liver functions. However, the precise mechanism underlying liver cirrhosis-induced muscle atrophy has not been elucidated. Here we show that serum factor induced by liver fibrosis leads to skeletal muscle atrophy. Using bile duct ligation (BDL) model of liver injury, we induced liver fibrosis in mice and observed subsequent muscle atrophy and weakness. We developed culture system of human primary myotubes that enables an evaluation of the effects of soluble factors on muscle atrophy and found that serum from BDL mice contains atrophy-inducing factors. This atrophy-inducing effect of BDL mouse ser

SUBMITTER: Kurosawa T 

PROVIDER: S-EPMC7791043 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature