PET evaluation of light-induced modulation of microglial activation and GLP-1R expression in depressive rats.

ABSTRACT: Light therapy has been accepted as a promising therapeutic choice for depression. Positron emission tomography (PET) combined with specific radiotracers has great benefits for revealing pathogenesis and developing therapeutics. This study aimed to investigate the influences of light therapy on microglial activation and glucagon-like peptide-1 receptor (GLP-1R) expression in the brain of depressive rats using [¹⁸F]DPA-714 and [¹⁸F]exendin-4 PET. The results showed that chronic unpredictable mild stress (CUMS)-induced depressive rats had poorer performance in behavioral tests compared to normal rats (p < 0.05) and the depressive-like behavior could be ameliorated by light therapy. Besides, depressive rats had significantly higher [¹⁸F]DPA-714 uptake and lower

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7791059 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature