Towards in vivo imaging of functionally active 5-HT_1A receptors in schizophrenia: concepts and challenges.

ABSTRACT: The serotonin 5-HT_1A receptor has attracted wide attention as a target for treatment of psychiatric disorders. Although this receptor is important in the pharmacological mechanisms of action of new-generation antipsychotics, its characterization remains incomplete. Studies based on in vitro molecular imaging on brain tissue by autoradiography, and more recently in vivo PET imaging, have not yielded clear results, in particular due to the limitations of current 5-HT_1A radiotracers, which lack specificity and/or bind to all 5-HT_1A receptors, regardless of their functional status. The new concept of PET neuroimaging of functionally active G-protein-coupled receptors makes it possible to revisit PET brain exploration by enabling new research paradigms. For the

SUBMITTER: Razakarivony O 

PROVIDER: S-EPMC7791062 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature