ILB^® resolves inflammatory scarring and promotes functional tissue repair.

ABSTRACT: Fibrotic disease is a major cause of mortality worldwide, with fibrosis arising from prolonged inflammation and aberrant extracellular matrix dynamics. Compromised cellular and tissue repair processes following injury, infection, metabolic dysfunction, autoimmune conditions and vascular diseases leave tissues susceptible to unresolved inflammation, fibrogenesis, loss of function and scarring. There has been limited clinical success with therapies for inflammatory and fibrotic diseases such that there remains a large unmet therapeutic need to restore normal tissue homoeostasis without detrimental side effects. We investigated the effects of a newly formulated low molecular weight dextran sulfate (LMW-DS), termed ILB^®, to resolve inflammation and activate matrix remodelling in rod

SUBMITTER: Hill LJ 

PROVIDER: S-EPMC7791102 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature