A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells.

ABSTRACT: Major depressive disorder is the most prevalent mental illness worldwide, still its pharmacological treatment is limited by various challenges, such as the large heterogeneity in treatment response and the lack of insight into the neurobiological pathways underlying this phenomenon. To decode the molecular mechanisms shaping antidepressant response and to distinguish those from general paroxetine effects, we used a previously established approach targeting extremes (i.e., good vs poor responder mice). We focused on the dentate gyrus (DG), a subregion of major interest in the context of antidepressant mechanisms. Transcriptome profiling on micro-dissected DG granule cells was performed to (i) reveal cell-type-specific changes in paroxetine-induced gene expression (paroxetine vs vehicle) and

SUBMITTER: Herzog DP 

PROVIDER: S-EPMC7791134 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature