Prognostic implication of systemic inflammatory markers in young patients with resectable colorectal cancer.

ABSTRACT:

Purpose

The prognosis of young colorectal cancer (CRC) patients has not fully been addressed. The prognostic significance of systemic inflammatory markers was examined in those patients.

Methods

A total of 965 patients with resectable CRC were divided into young (≤ 50 years, n = 101) and old groups (> 51 years, n = 864). Neutrophil-to-lymphocyte ratio (NLR) > 5, derived NLR (dNLR) > 3, lymphocyte-to-monocyte ratio (LMR) < 2, platelet-to-lymphocyte ratio (PLR) > 150, and prognostic nutritional index (PNI) < 45 were analyzed for prognosis. Overall survival (OS) and progression-free survival (PFS) were compared using the log-rank test. A multivariate analysis was performed using a Cox proportional hazards regression model.

Results

In the young group, NLR > 5, LMR < 2, an

SUBMITTER: Lee SY 

PROVIDER: S-EPMC7791188 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature