Insights into the association between coagulopathy and inflammation: abnormal clot mechanics are a warning of immunologic dysregulation following major injury.

ABSTRACT:

Background

Severe injury initiates a complex physiologic response encompassing multiple systems and varies phenotypically between patients. Trauma-induced coagulopathy may be an early warning of a poorly coordinated response at the molecular level, including a deleterious immunologic response and worsening of shock states. The onset of trauma-induced coagulopathy (TIC) may be subtle however. In previous work, we identified an early warning sign of coagulopathy from the admission thromboelastogram, called the MAR ratio. We hypothesized that a low MAR ratio would be associated with specific derangements in the inflammatory response.

Methods

In this prospective, observational study, 88 blunt trauma patients admitted to the intensive care unit (ICU) were identified. Concentratio

SUBMITTER: Savage SA 

PROVIDER: S-EPMC7791215 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature