Chromatin-regulating genes are associated with postoperative prognosis and isocitrate dehydrogenase mutation in astrocytoma.

ABSTRACT:

Background

Abnormality in chromatin regulation is a major determinant in the progression of multiple neoplasms. Astrocytoma is a malignant histologic morphology of glioma that is commonly accompanied by chromatin dysregulation. However, the systemic interpretation of the expression characteristics of chromatin-regulating genes in astrocytoma is unclear.

Methods

In this study, we investigated the expression profile of chromatin regulation genes in 194 astrocytoma patients sourced from The Cancer Genome Atlas (TCGA) database. The relevance of gene expression and postoperative survival outcomes was assessed.

Results

Based on the expression patterns of chromatin regulation genes, two primary clusters and three subclusters with significantly different survival outcomes wer

SUBMITTER: Zhang K 

PROVIDER: S-EPMC7791220 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature