Branched-chain amino acids are linked with iron metabolism.

ABSTRACT:

Background

The branched-chain amino acids (BCAAs) valine, leucine and isoleucine are reported to influence erythropoiesis and the human iron status. Large study cohorts encompassing biomarkers of iron metabolism and BCAAs are still lacking.

Methods

We investigated potential interactions between blood concentrations of all three BCAAs valine, leucine and isoleucine and biomarkers of iron metabolism [i.e., hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), iron, transferrin, ferritin, transferrin saturation, soluble transferrin receptor (sTfR)] in 430 outpatients referred for a medical health check-up. Linear regression models were performed to assess possible associations between variables.

Results

All three BCAAs were positively correla

SUBMITTER: Enko D 

PROVIDER: S-EPMC7791222 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature