Clinical implications of serum Mac-2-binding protein glycan isomer as a novel biomarker of advanced hepatic fibrosis in diabetes.

ABSTRACT:

Background

Appropriate strategy for screening, identification, and linkage to care of patients with advanced fibrosis in the general population is a current issue. The aim of this study was to find reference values and the clinical role of Mac-2 binding protein glycan isomer (M2BPGi) in a health check-up setting.

Methods

This study was designed as cross-sectional study. Adult subjects (n=1,073) who underwent a health check-up were included in the final analysis, and 952 subjects with risk factors for liver disease and insufficient data were excluded. M2BPGi quantification was based on a lectin antibody sandwich immunoassay. Fatty liver was diagnosed using abdominal sonography.

Results

The reference value of M2BPGi was 0.5-1.0 cut off index (COI) in the average risk gr

SUBMITTER: Park H 

PROVIDER: S-EPMC7791238 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature