Infection biomarkers in assisting the judgement of blood stream infection and patient prognosis: a retrospective study incorporating principal components analysis.

ABSTRACT:

Background

This study aimed to evaluate whether inexpensive and quickly available infection biomarkers including procalcitonin (PCT), C-reactive protein (CRP), white blood cell (WBC) count, and percentage of neutrophils (N%) are helpful in assisting the judgement of blood culture results and patient prognosis.

Methods

This retrospective study included patients who were admitted to the intensive care unit (ICU) of Changzheng Hospital from July 2015 to June 2017 and had at least one episode of blood culture with matched infection biomarkers (PCT, CRP, WBC, and N%). Primary infection biomarkers were transformed into newly derived components using the principal component analysis (PCA) method. Each observation was plotted as a point on the component map using factor scores as co

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7791242 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature