Gene Signatures and Prognostic Values of m6A RNA Methylation Regulators in Ovarian Cancer.

ABSTRACT:

Background

N6-methyladenosine (m6A) is the most common form of mRNA modification under the field of "RNA epigenetics." However, its role in ovarian cancer (OC) development is poorly understood. In the current study, we aimed to identify gene signatures and prognostic values of m6A RNA methylation regulators.

Method

Specifically, we downloaded Mutations and Copy number variant (CNV) data from the TCGA database for 579 OC patients, then analyzed gene expression and prognosis value using integrative bioinformatics. Thereafter, we verified the related biological processes of Wilms' tumor 1-associating protein (WTAP) gene using Gene set enrichment analysis (GSEA).

Results

Results showed that almost all ovarian cancer patients (99.31%) have CNVs with at least 1 m6A regulato

SUBMITTER: Han X 

PROVIDER: S-EPMC7791456 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature