Microengineered Human Vein-Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis.

ABSTRACT: Deep vein thrombosis (DVT) and its consequences are lethal, but current models cannot completely dissect its determinants-endothelium, flow, and blood constituents-together called Virchow's triad. Most models for studying DVT forego assessment of venous valves that serve as the primary sites of DVT formation. Therefore, the knowledge of DVT formed at the venous cusps has remained obscure due to lack of experimental models. Here, organ-on-chip methodology is leveraged to create a Vein-Chip platform integrating fully vascularized venous valves and its hemodynamic, as seen in vivo. These Vein-Chips reveal that vascular endothelium of valve cusps adapts to the locally disturbed microenvironment by expressing a different phenotype from the regions of uniform flow. This spatial adaptation of end

SUBMITTER: Rajeeva Pandian NK 

PROVIDER: S-EPMC7791597 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature