Prostate-Specific Antigen Screening and Recent Increases in Advanced Prostate Cancer.

ABSTRACT: Recent studies show decreasing prostate-specific antigen utilization and increasing incidence of metastatic prostate cancer in the United States after national recommendations against screening in 2012. Yet, whether the increasing incidence of metastatic prostate cancer is consistent in magnitude with the expected impact of decreased screening is unknown. We compared observed incidence of metastatic prostate cancer from the Surveillance, Epidemiology, and End Results program and published effects of continued historical screening and discontinued screening starting in 2013 projected by 2 models of disease natural history, screening, and diagnosis. The observed rate of new metastatic prostate cancer cases in 2017 was 44%-60% of the projected increase under discontinued screening relative to

SUBMITTER: Nyame YA 

PROVIDER: S-EPMC7791607 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature