Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study.

ABSTRACT: We previously investigated the association between 5 "first-generation" measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study. This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length. We estimated rate ratios (RRs) for the association between these 3 age-adjusted measures and risk of colorectal (N = 813), gastric (N = 165), kidney (N = 139), lung (N = 327), mature B-cell (N = 423), prostate (N = 846), and urothelial (N = 404) cancer using conditional logistic regression models. We also assessed associations by time since blood draw and by cancer subtype, and we investigated potential nonlinearity. We observed relatively strong associations of age-adjusted

SUBMITTER: Dugue PA 

PROVIDER: S-EPMC7791618 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature